UFC 265 predictions: Who picks Derrick Lewis to upset 4-1 favorite Ciryl Gane for interim title?

	Lewis vs. Gane	Aldo vs. Munhoz	Chiesa vs. Luque	Hill vs. Torres	Kenney vs. Yadong
MMA Junkie readers’ consensus picks 2021: 117-70	Lewis (61%)	Aldo (59%)	Luque (51%)	Hill (50.1%)	Yadong (55%)
Ken Hathaway @kenshathaway 2021: 117-70 2018 Champion	Lewis	Munhoz	Chiesa	Torres	Kenney
John Morgan @MMAjunkieJohn 2021: 116-71	Gane	Aldo	Chiesa	Torres	Kenney
Simon Samano @SJSamano 2021: 115-72	Lewis	Aldo	Chiesa	Torres	Yadong
Dan Tom @DanTomMMA 2021: 112-75 2020 Champion	Gane	Aldo	Chiesa	Torres	Kenney
Matt Erickson @MMAjunkieMatt 2021: 111-76	Lewis	Munhoz	Luque	Hill	Yadong
Nolan King @mma_kings 2021: 111-76	Gane	Aldo	Luque	Hill	Kenney
George Garcia @MMAjunkieGeorge 2021: 110-77	Lewis	Aldo	Chiesa	Torres	Kenney
Mike Bohn @MikeBohnMMA 2021: 110-77 2014 Champion	Gane	Munhoz	Luque	Torres	Yadong
Danny Segura @dannyseguratv 2021: 109-78	Gane	Aldo	Luque	Hill	Kenney
Farah Hannoun @Farah_Hannoun 2021: 108-79	Gane	Aldo	Luque	Torres	Kenney
Brian Garcia @thegoze 2021: 108-79 2017 Champion	Lewis	Aldo	Chiesa	Hill	Yadong
Abbey Subhan @kammakaze 2021: 106-81	Lewis	Aldo	Chiesa	Torres	Kenney
Matthew Wells @MrMWells 2021: 42-29	Lewis	Aldo	Chiesa	Hill	Kenney
Tipico Betting Favorites	Gane -400	Aldo -120	Luque -125	Torres -145	Kenney -120

The UFC is back in Texas in front of fans this week, and an interim belt is on the line.

UFC 265 takes place Saturday at Toyota Center in Houston. The main card airs on pay-per-view following prelims on ESPN and early prelims on ESPN+.

(Click here to open a PDF of the staff picks grid in a separate window.)

In the main event, Houston native Derrick Lewis (25-7 MMA, 16-5 UFC) takes on Ciryl Gane (9-0 MMA, 6-0 UFC) for the interim heavyweight title. Gane is a sizable betting favorite at -400 at Tipico, but it’s Lewis with a 7-6 edge in the picks from our 13 editors, writers, radio hosts and videographers.

In the co-feature, former featherweight champion Jose Aldo (29-7 MMA, 11-6 UFC) continues his run at bantamweight when he takes on Pedro Munhoz (19-5 MMA, 9-5 UFC). Aldo is just a slight favorite at -120, and only three of our pickers are going against him.

Also on the main card, Michael Chiesa (17-4 MMA, 11-4 UFC) takes on Vicente Luque (20-7-1 MMA, 13-3 UFC) in a key welterweight matchup. Luque is just a slight favorite at -125, but it’s Chiesa who has an 8-5 lead in the picks.

Angela Hill (13-9 MMA, 8-9 UFC) meets Tecia Torres (12-5 MMA, 8-5 UFC) in a women’s strawweight bout. Torres is a -145 favorite at the betting window, and she’s got a slim edge in our picks at 8-5.

And to open the main card, Casey Kenney (16-3-1 MMA, 5-2 UFC) is a -120 favorite at bbantamweight against Song Yadong (16-5-1 MMA, 5-1-1 UFC), but he’s got a big picks lead at 9-4.

In the MMA Junkie reader consensus picks, Lewis (61 percent), Aldo (59 percent), Luque (51 percent), Hill (50.1 percent) and Yadong (55 percent) are the choices.

Check out all the picks above.